Novel cutting-edge metabolite-based diagnostic tools for aspergillosis

Novel cutting-edge metabolite-based diagnostic tools for aspergillosis

Metabolite-based detection of aspergillosis Aspergillosis is a group of diseases caused by the inhalation of ubiquitous Aspergillus spores, generally Aspergillus fumigatus [1], that evade the host immune system [2]. Its most aggressive form, invasive aspergillosis (IA), carries a particularly grim prognosis in immunocompromised patients [2]. High mortality and the associated socioeconomic burde...

Cutting Edge: BASH, A Novel Signaling

Mechanics of high speed cutting with curvilinear edge tools

High speed cutting is advantageous due to the reduced forces and power, increased energy savings, and overall improved productivity for discrete-part metal manufacturing. However, tool edge geometry and combined cutting conditions highly affects the performance of high speed cutting. In this study, mechanics of cutting with curvilinear (round and oval-like) edge preparation tools in the presenc...

How to Train a Cell–Cutting-Edge Molecular Tools

In biological systems, the formation of molecular complexes is the currency for all cellular processes. Traditionally, functional experimentation was targeted to single molecular players in order to understand its effects in a cell or animal phenotype. In the last few years, we have been experiencing rapid progress in the development of ground-breaking molecular biology tools that affect the me...

Novel needle cutting edge geometry for end-cut biopsy.

PURPOSE To introduce and determine the biopsy length performance of the novel enhanced cutting edge (ECE) needle tip design, which contains high inclination angles that allow for more efficient tissue cutting. METHODS ECE and regular two-plane symmetric needle tip's biopsy performance and cutting force are compared over a series of needle insertion experiments into bovine liver under varying ...